Antibiotikaresistens särskilt av gramnegativa bakterier har nästan skapat en krisliknande situation. Det nya antibiotikumet Zosurabalpin (RG6006) visar löften. Det har visat sig vara effektivt mot läkemedelsresistenta, gramnegativa bakterier CRAB i prekliniska studier.
Antimicrobial resistance (AMR), driven mainly by the misuse and overuse of antimicrobials, is one of top public health risk.
Infections by Gram-negative bacteria are particularly concerning. It is not easy for most of antibiotika to cross both inner and outer membranes present in this category of bacteria to enter the bacterial cells to show bactericidal actions. Also, Gram-negative bacteria have accumulated disproportionately high degree of antibiotikum motstånd.
Acinetobacter baumannii is a Gram-negative bacterium. Infection by one of its strains called ‘carbapenem-resistant Acinetobacter baumannii’ (CRAB) is hard to treat using available antibiotika. There is an urgent need for an effective antibiotikum against CARB as mortality rate is high (about 40%-60%) which attributed largely to lack of an effective antibiotikum. A progress towards this goal has been reported.
Scientists have identified a novel class of antibiotika namely, tethered macrocyclic peptides (MCPs) which are active against the Gram –ve bacteria A. baumannii including CARB by blocking transport of bacterial lipopolysaccharide from the inner membrane to the outer membrane.
Zosurabalpin (RG6006) är en antibiotikum candidate belonging to ‘tethered macrocyclic peptides (MCPs)’ class. In pre-kliniska trials involving in vitro studies and in vivo studies on animal models, Zosurabalpin has been found to be effective against drug-resistant isolates of ‘carbapenem-resistant Acinetobacter baumannii’ (CRAB) from different regions. It successfully overcame antibiotikum-resistance mechanism of CARB suggesting Zosurabalpin har potential.
Hence, human kliniska trials have been initiated to check for safety and efficacy Zosurabalpin vid behandling av invasiva infektioner orsakade av KRABBA.
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Referenser:
- Zampaloni, C., Mattei, P., Bleicher, K. et al. A novel antibiotikum class targeting the lipopolysaccharide transporter. Nature (2024). https://doi.org/10.1038/s41586-023-06873-0
- Hawser S., et al, 2023. Activity of the Novel Antibiotic Zosurabalpin (RG6006) against Klinisk Acinetobacter Isolates from China, Open Forum Infectious Diseases, Volume 10, Issue Supplement_2, December 2023, ofad500.1754, https://doi.org/10.1093/ofid/ofad500.1754
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